Mortality Risk can increase with Chronic Fluid Overload in Dialysis Patients


  • Over a year of overload in cumulative fluid results in a higher risk of death than the single measurement made at the beginning of regular dialysis treatment, researchers found.
  • Recent research indicates that sustained fluid overload increases the risk of mortality in patients with renal failure patients during hemodialysis resulting in consequences like discomfort, swelling, hypertension, and heart problems.
  • An extensive clinical database of a large international dialysis network was analyzed by Carmine Zoccali, MD, from CNR-IFC, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension of Reggio Calabria, Italy, along with his colleagues.

Studies were based on more than 200,000 measurements of fluid status in 39,566 patients starting hemodialysis in 26 countries in Africa, Europe, Latin America, and the Middle East. An article titled “Chronic Fluid overload and mortality in ESRD” published the findings in a future copy of the Journal of the American Society of Nephrology.

The study was structured around examining the relationship between fluid overload measured only once at the beginning of regular dialysis treatment and mortality, in conjunction with the relationship between cumulative exposure to fluid overload over a year and mortality.

  • Zoccali said that this is the first research that presents the information about the risk of constant fluid overload in dialysis patients. He also added that the overmuch risk for death attributable to continuous fluid overload was similar to the risk found in coronary artery disease, heart failure, and being 12 years older.
  • Ulrich Moissl, PhD, Francesca Mallamaci, MD, Charles Chazot, MD, Giovanni Tripep, Dr Biostat, PhD, Peter Wabel, PhD, Otto Arkossy, MD, and Stefano Stuard, MD, PhD made the team of co-authors of the study.

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